- Sequential C-N and C-O bond formation in a single pot: Synthesis of 2 H -benzo[ b ][1,4]oxazines from 2,5-dihydroxybenzaldehyde and amino acid precursors
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Functionalized β-aryl alanine ester derivatives were found to undergo rapid C-N and C-O bond formation with quinol carbonyl compounds to afford 2H-benzo[b][1,4]oxazines in good to excellent yields. This unprecedented finding reported herein offers a straightforward, highly efficient, and rapid method for the synthesis of 2H-benzo[b][1,4]oxazines.
- Iqbal, Javed,Tangellamudi, Neelima D.,Dulla, Balakrishna,Balasubramanian, Sridhar
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supporting information; experimental part
p. 552 - 555
(2012/03/11)
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- Ethyl N-(diphenylmethylene)glycinate as anionic glycine equivalent. Monoalkylation, dialkylation and michael additions under solid-liquid phase-transfer catalysis
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Ethyl N-(diphenylmethylene)glycinate, 1, undergoes monoalkylations, dialkylations and Michael additions to ethylenic and acetylenic acceptors under appropriate solid-liquid phase transfer catalysis conditions. Further transformations of the α-disubstituted ketimines lead to α-alkylated aspartic and glutamic acid derivatives 10, 15, 19 and 26, to bicyclic amino acids or derivatives featuring pyrazolone and isoxazolone moieties 30 and 33, and to α-substituted (E)-3,4-dehydroglutamic acids. Copyright
- Lopez, Anna,Moreno-Manas, Marcial,Pleixats, Roser,Roglans, Anna,Ezquerra, Jesus,Pedregal, Concepcion
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p. 8365 - 8386
(2007/10/03)
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- Synthesis of α-substituted and α,α-disubstituted α-amino acids by controlled mono- and dialkylation of ethyl N-diphenylmethyleneglycinate
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Ethyl N-diphenylmethyleneglycinate reacts with one equivalent of alkylating agents in the presence of powdered potassium carbonate to afford, after hydrolysis, monoalkylated glycine esters. A similar process using two equivalents of alkylating agents in t
- Ezquerra,Pedregal,Moreno-Manas,Pleixats,Roglans
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p. 8535 - 8538
(2007/10/02)
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- UNUSUAL N-ACYLATION OF GLYCINE SCHIFF BASES. A SIMPLE APPROACH TO 3,3-DIPHENYLAZIRIDINE-2-CARBOXYLATES
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Treatment of azaallyl anions, generated from glycine Schiff bases, with Ar-acyl halides furnishes N-acylaziridines via intramolecular cyclization.
- Rao, M. Narayana,Holkar, A. G.,Ayyangar, N. R.
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p. 4717 - 4720
(2007/10/02)
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