Antitumor agents. 113. New 4β-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II
A number of 4'-O-demethylepipodophyllotoxin derivatives possessing various 4β-N-, 4β-O- or 4β-S-aromatic rings have been synthesized and evaluated for their inhibitory activity against the human DNA topoisomerase II as well as for their activity in causin
Wang,Kuo,Schnur,Bowen,Liu,Han,Chang,Cheng,Lee
p. 2660 - 2666
(2007/10/02)
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