- Active brilliant blue K-GR method for the preparation of intermediates
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The invention provides a preparation method of a reactive brilliant blue K-GR intermediate. The preparation method comprises following steps: carrying out a condensation reaction between bromamine acid and 2,4-diaminobenzene sulfonic acid or sodium 2,4-diaminobenzene sulfonate with a catalyst system containing a cuprous complex for catalyzing the reaction to obtain the reactive brilliant blue K-GR intermediate (sodium 1-amino-4-((4-amino-3-sulfonylphenyl)amino)-anthraquinone-2-sulfonate). By means of the preparation method of the reactive brilliant blue K-GR intermediate, usage amounts of cuprous chloride and copper powder can be effectively reduced, thereby reducing the content of heavy metals in a dye product, reducing the content of heavy metals in waste water and reducing environmental pollution and production cost. In addition, the preparation method can avoid generation of a hydrolyzed by-product (a purple by-product) of the bromamine acid, can greatly reduce the generation of a debromination by-product, can significantly reduce the generation of a double-condensation substance, can increase yields of the condensation reaction and the dye product and can reduce discharge amount of waste water containing acids and being high in chroma.
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Paragraph 0040-0042
(2017/05/18)
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- METHOD FOR PURIFICATION OF ANTIBODIES, ANTIBODY FRAGMENTS OR ENGINEERED VARIANTS THEREOF USING SPECIFIC ANTHRAQUINONE DYE-LIGAND STRUCTURES
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The present invention relates to novel adsorbents applicable a process for the separation or purification of antibodies, antibody fragments or engineered variants thereof, which comprise anthraquinone dye ligands; corresponding purification processes; and corresponding analytical or preparative separation kits.
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Page/Page column 33; 34
(2015/09/23)
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- Triazine compounds and method for dyeing or printing fiber materials using the same
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A triazine compound which is useful for dyeing or printing materials containing hydroxyl group and/or amide group, and which has the following formula (I) or salts thereof STR1 wherein R represents hydrogen or unsubstituted or substituted alkyl; R1 represents hydrogen, an alkyl unsubstituted or substituted by carboxy, sulfo, alkoxy, halogeno, sulfato or hydroxy, or --Y--SO2 Z3 ; R2 represents hydrogen or unsubstituted or substituted alkyl; A represents unsubstituted or substituted phenylene or naphthylene; Y represents a divalent group which is C2 -C7 alkylene and so on; Z1, Z2 and Z3 independently of one another are each --CH=CH2 or --CH2 CH2 Z' wherein Z' is a group capable of being split by the action of an alkali; and F is any one of the dye residue which is anthraquinone, azo, disazo, trisazo or phthalocyanine nucleus and so on, and a process for dyeing or printing fiber materials which comprises using said triazine compounds or salts thereof.
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- MECHANISM OF THE ULLMANN CONDENSATION
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It has been found that the condensation rate of 1-amino-4-bromoanthraquinone-2-sulphonic acid (I) with 1,3-diaminobenzene-4-sulphonic acid (II)giving 1-amino-4-(3'-amino-4'-sulphoanilino)anthraquinone-2-sulphonic acid (III) in media of NaHCO3 - CO2 and NaHCO3 - Na2CO3 with catalysis by CuI obeys the kinetic relation v = k, being controlled by the kinetic relation v = k2 in media of NaH2PO4 - Na2HPO4 buffers.The suggested reaction mechanism presumes formation of a bifunctional catalyst CuCO3 or Cu2PO4(1-) which splits off the proton and bromide anion from the reaction intermediate in the rate-limiting step.
- Vrba, Zdenek
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