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128071-79-4

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INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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Paragraph 00243

(2018/12/03)

TRIAZOLOPYRIDINE COMPOUNDS AND USES THEREOF
A compound of Formula (IA), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein A, R6, R7 and R8 are as defined herein.
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Paragraph 00188

(2018/04/11)

Migration du lithium en serie pyridinique: double catalyse et reformage. Acces aux derives de la bromo-2 lithio-3 pyridine et des bromo-4 halogeno-2 lithio-3 pyridines
The lithium of an organolithium-pyridinic derivative can be moved from one position to an another by an intermolecular reaction.Two new reactions are possible for pyridinic organic synthesis: the isomerisation of any lithio derivative to a more stable one, and a reaction that transforms a mixture of various bromo-lithio derivatives into a single one.The processes involved and the experimental tools used are described in terms of the 2-bromo-3-lithio- and 4-bromo-2-halogeno-3-lithiopyridines derivatives synthesis.
Mallet, Marc,Branger, Gilles,Marsais, Francis,Queguiner, Guy
p. 319 - 332
(2007/10/02)

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7631-86-9
SiO₂

Chemical Properties

Boiling Point: 220.2 °C at 760 mmHg
Flash Point:87 °C
Density: 1.592g/cm³
Solubility:Chloroform (Slightly), Methanol (Slightly)
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Vapor Pressure: 0.17mmHg at 25°C
Refractive Index: 1.529
PKA: 1.05±0.10(Predicted)
PSA: 12.89000
LogP: 2.29160

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