- AZABICYCLIC(THIO)AMIDES AS FUNGICIDAL COMPOUNDS
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The present invention relates to azabicyclic (thio)amide compounds and the uses thereof for controlling phytopathogenic microorganisms such as phytopathogenic fungi. It also relates to processes and intermediates for preparing these compounds
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Page/Page column 145
(2021/11/26)
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- MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
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The present invention relates to compounds of formula (I), or their isotopic forms, stereoisomers, tautomers or pharmaceutically acceptable salt (s) thereof as muscarinic M1 receptor positive allosteric modulators (M1 PAMs). The present invention describes the preparation, pharmaceutical composition and the use of compound formula (I).
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Page/Page column 111
(2018/03/25)
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- GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES
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Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).
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Paragraph 000788
(2015/04/15)
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- Dual SNAr reaction in activated ortho-halonitrobenzene: Direct synthesis of substituted 1,2,3,4-tetrahydroquinoxalines, 2,3-dihydro-1,4- benzoxazines, and 1,4-benzodioxines
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An unprecedented one-pot synthesis of substituted 1,2,3,4- tetrahydroquinoxalines, 2,3-dihydro-1,4-benzoxazines, and 1,4-benzodioxines from activated ortho-halonitrobenzenes has been accomplished by dual nucleophilic aromatic substitution (SNAr
- Deshmukh, Mahesh S.,Das, Biswajit,Jain, Nidhi
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p. 22389 - 22396
(2013/11/06)
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- CARBINOL DERIVATIVES HAVING HETEROCYCLIC LINKER
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[Object] It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C—R7; each X and Y independently show CH2, C═O, SO2, etc; Z shows CH or N; each R1, R2 and R7 independently show a hydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows an optionally substituted C6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)
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Page/Page column 49
(2010/12/29)
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- 8-Piperazinyl-2,3-dihydro-1,4-dioxinopyridine Derivatives: Synthesis and Interaction with 5-HT Serotonin Binding Sites
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The synthesis of 8-piperazinyl-2,3-dihydro-1,4-dioxinopyridine derivatives (6a-c) are described.Their affinity and selectivity for 5-HT serotoninergic sites were evaluated.
- Joseph, Benoit,Benarab, Abdelhakim,Guillaumet, Gerald
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p. 1355 - 1360
(2007/10/02)
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- 1,4-Dioxinopyridines and 1,4-Oxathiinopyridines
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Reaction of 3-hydroxy-2-pyridones 1 or 3-hydroxy-2-pyridinthiones 2 with sodium hydride and 1,2-dibromoethane in hexamethylphosphorous triamide gives 1,4-dioxinopyridines 3 and 1,4-oxathiinopyridines 4, respectively.Nitration of 3 affords nitro-1,4-dioxinopyridines 5 which can be hydrogenated to amino-1,4-dioxinopyridines 7.
- Neunhoeffer, Hans,Sponheimer, Otto
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p. 2453 - 2454
(2007/10/02)
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