Synthesis of a photoaffinity-labeled (11Z)-retinal: Identification of retinal/rhodopsin cross-linked sites along the visual-transduction path
The retinal chromophore (11Z)-3-diazo-4-oxoretinal (1) with two photo-labile moieties has been synthesized by semi-hydrogenation of an 11-yne precursor with activated Zn in aqueous media. Incorporation of 1 into opsin yielded diazoketo rhodopsin (DK-Rh),
Souto, Maria L.,Um, Joann,Borhan, Babak,Nakanishi, Koji
p. 2617 - 2628
(2007/10/03)
Chemoenzymatic synthesis of 11-cis-retinal photoaffinity analog by use of squid retinochrome
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Borhan,Kunz,Wang,Nakanishi
p. 5758 - 5759
(2007/10/03)
Photoaffinity labeling studies of bacteriorhodopsin with [ 15-3H]-3-diazo-4-keto-all-trans-retinal
Photoaffinity mapping can be used to help clarify the tertiary structures of the retinal proteins bacteriorhodopsin (bR) and rhodopsin (Rh). An efficient photoaffinity labeled retinal analogue, [l5-3H]-all-trans-3-diazo-4-ketoretinal (specific
Boehm, Marcus F.,Gawinowicz, Mary Ann,Foucault, Alain,Derguini, Fadila,Nakanishi, Koji
p. 7779 - 7782
(2007/10/02)
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