- Alternative method for the reduction of aromatic nitro to amine using TMDS-iron catalyst system
-
The system 1,1,3,3-tetramethyldisiloxane (TMDS)/Fe(acac)3 is reported here as a new method to obtain amines from aromatic nitro compounds. Amines are synthetized in a straightforward step and are isolated as hydrochloride salts with good to excellent yields. This system has shown a good selectivity toward aryl-chloride, aryl-bromide, ester, carboxylic acid, and cyano groups. The reduction of alkylnitro compounds was unfortunately not possible using this method, only a mixture of mono and dialkylated amine was obtained.
- Pehlivan, Leyla,Métay, Estelle,Laval, Stéphane,Dayoub, Wissam,Demonchaux, Patrice,Mignani, Gérard,Lemaire, Marc
-
experimental part
p. 1971 - 1976
(2011/04/22)
-
- Carboxyl-Mediated Pictet-Spengler Reaction. Direct Synthesis of 1,2,3,4-Tetrahydro-β-carbolines from Tryptamine-2-carboxylic Acids
-
The Pictet-Spengler condensation of various tryptamine-2-carboxylic acids 9a-f with carbonyl compounds in benzene/dioxane/trifluoroacetic acid (Table I) with simultaneous loss of carbon dioxide afforded directly the corresponding 1,2,3,4-tetrahydro-β-carb
- Narayanan, Krishnaswamy,Schindler, Liesl,Cook, James M.
-
p. 359 - 365
(2007/10/02)
-