- Synthesis of different substituted pyridazinone derivatives and their anticonvulsant activity
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6-Phenyl(3'-imino-benzylidene)-2,3,4,5-tetrahydro pyridazin-3-one derivatives were synthesized from 6-(3'-aminophenyl)-2,3,4,5-tetrahydro pyridazin-3-one by reaction with different aldehydes. The respective pyridazinone was prepared by cyclization of appropriate β-(aminophenyl) propionic acid with hydrazine hydrate. The pyridazinone derivatives were tested for anticonvulsant activity by MES (maximal electro shock) method and found that few of them have shown significant anticonvulsant activity.
- Samanta, Kartick Chandra,Asif, Mohd.,Pooja,Garg, Vikas,Sharma, Priyanka,Singh, Ravinder
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p. 245 - 251
(2012/02/04)
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