- ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE
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The present invention is directed to novel compounds of Formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof. Pharmaceutical compositions comprising a compound of Formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof, are also described. The invention is also directed to use of the compounds of Formula (I) for treating a condition in a mammal associated with AhR imbalance, such as an inflammatory disease or disorder.
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- Total synthesis of agastaquinone, a diterpenoid quinone isolated from Agastache rugosa
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Agastaquinone is a tricyclic diterpenoid isolated from Agastache rugose. The first total synthesis of agastaquinone was accomplished based on intramolecular Friedel-Crafts acylation of aryl lactone followed by aromatization leading to the tricyclic phenol
- Lee, Sangku,Yoo, Jisu,Jung, Jae-Kyung,Kim, Jae Nyoung,Yoon, Myeong Sik
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supporting information
p. 134 - 138
(2020/10/02)
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- Enantioselective total syntheses of (-)-taiwaniaquinone H and (-)-taiwaniaquinol B by iridium-catalyzed borylation and palladium-catalyzed asymmetric α-arylation
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We report a concise, enantioselective total synthesis of (-)-taiwaniaquinone H and the first enantioselective total synthesis of (-)-taiwaniaquinol B by a route that includes asymmetric palladium-catalyzed α-arylation of a ketone with an aryl bromide that
- Liao, Xuebin,Stanley, Levi M.,Hartwig, John F.
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p. 2088 - 2091
(2011/04/16)
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