Enantioselective gem -chlorofluorination of active methylene compounds using a chiral spiro oxazoline ligand
Highly enantioselective gem-chlorofluorination of active methylene compounds was carried out by using a copper(II) complex of a chiral spiro pyridyl monooxazoline ligand. This reaction yielded α-chloro-α- fluoro-β-keto esters and α-chloro-α-fluoro-β-keto