PEG-mediated catalyst-free expeditious synthesis of polysubstituted anilines and benzenes via the reaction of malononitrile and β-ketoester derivatives in the presence of activated acetylenes
Poly(ethylene glycol) (PEG) has been used as a sustainable, non-volatile, and environmentally friendly reaction solvent for synthesis of functionalized anilines and benzenes via the reaction of malononitrile and β-ketoester derivatives in the presence of activated acetylenes at 80o C. No additional solvent and catalyst are required.
Piltan, Mohammad,Moradi, Loghman,Salimi, Hiwa,Zargoosh, Kiomars,Zarei, Seyed Amir
p. 571 - 575
(2012/11/13)
COPPER(II) IN ORGANIC SYNTHESIS. IX . THE COPPER(II)-CATALYZED MICHAEL REACTION AS A ROUTE TO POLYSUBSTITUTED BENZENE DERIVATIVES
A new synthetic method to polysubstituted benzene derivatives is reported.
Desimoni, Giovanni,Invernizzi, Anna Gamba,Quadrelli, Paolo,Righetti, Pier Paolo
p. 483 - 485
(2007/10/02)
Reactions of Malononitrile with Acetylenic Esters and Ketones
The addition of malononitrile to acetylenic esters and acetylenic ketones catalysed by sodium alkoxides leads to the formation of 3- and 5-cyano-2-pyridones, 2-cyano- and 2,6-dicyano-aniline derivatives, and other products.
Kandeel, Kamal A.,Vernon, John M.,Dransfield, Trevor A.,Fouli, Fouli A.,Youssef, Ahmed S. A.
p. 2101 - 2117
(2007/10/02)
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