- Copper-catalyzed cross-coupling of functionalized alkyl halides and tosylates with secondary and tertiary alkyl Grignard reagents
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Added value: A copper-based method is highly efficient for the cross-coupling of alkyl electrophiles with secondary and tertiary alkyl Grignard reagents. The method is distinguished by its broad substrate scope and high functional group tolerance. Copyright
- Ren, Peng,Stern, Lucas-Alexandre,Hu, Xile
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supporting information
p. 9110 - 9113
(2012/10/29)
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- 7-oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
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7-Oxabicycloheptane substituted prostaglandin analogs useful in treating thrombotic and vasopastic disease have the structural formula STR1 wherein m is 1, 2 or 3; n is 1, 2, 3 or 4; Z is --(CH2)2 --, --CH=CH-- or STR2 wherein Y is O, a single bond or vinyl, with the proviso that when n is 0, if Z is STR3 then Y cannot be O, and Z is --CH=CH--, n is 1, 2, 3 or 4; and when Y=vinyl, n=0; R is CO2 H, CO2 lower alkyl, CH2 OH, CO2 alkali metal, CONHSOR3, CONHR3a or --CH2 --5-tetrazolyl, X is O, S or NH; and where R1, R2, R3 and R3a are as defined herein.
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- Process for preparing silver catalysts
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A silver salt solution suitable for depositing silver on a support in the preparation of silver cata-lysts is made by reacting a silver compound with a neo-acid, in a hydrocarbon solvent. The reaction is completed under reflux conditions, thereby removing water formed by the rection and reacting at least 90% of the unreacted acid. The solution may be used without further processing to impregnate a porous support, thereby providing a catalyst useful for oxida-tion of ethylene oxide.
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