Ligand-accelerated enantioselective propargylation of aldehydes via allenylzinc reagents
An enantioselective propargylation of aldehydes using an allenylzinc reagent generated in situ via a zinc-iodine exchange reaction is described. The enantioselectivity is controlled by addition of a catalytic amount of readily accessible and highly tunable amino alcohol ligand L13. A wide range of aldehydes can be propargylated to afford valuable and versatile homopropargyl alcohols in good to excellent yields with high levels of enantiopurity.
Trost, Barry M.,Ngai, Ming-Yu,Dong, Guangbin
supporting information; experimental part
p. 1900 - 1903
(2011/06/21)
A Catalytic Enantioselective Synthesis of Denopamine, a Useful Drug for Congestive Heart Failure
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Corey, E. J.,Link, John O.
p. 442 - 444
(2007/10/02)
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