- Thermally-Induced Intramolecular [4+2] Cycloaddition of Allylamino- or Allyloxy-Tethered Alkylidenecyclopropanes
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A thermally-induced intramolecular [4+2] cycloaddition reaction of allylamino- or allyloxy-tethered alkylidenecyclopropanes has been reported in this paper, giving a new protocol for the rapid construction of polycyclic skeleton molecules in moderate to e
- Tao, Leyi,Wei, Yin,Shi, Min
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supporting information
p. 2463 - 2468
(2021/07/21)
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- Synthesis of Allyl- and Prenylcoumarins via Microwave-Promoted Tandem Claisen Rearrangement/Wittig Olefination
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Allyl, dimethylallyl, crotyl, and prenyl ethers of various aromatic ortho-hydroxy carbonyl compounds undergo a tandem sequence of Claisen rearrangement, carbonyl olefination, and cyclization upon microwave irradiation in the presence of a stabilized ylide. The products are multiply substituted 6- or 8-allylated or prenylated coumarins (2H-chromen-2-ones).
- Schmidt, Bernd,Riemer, Martin
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supporting information
p. 141 - 149
(2015/12/26)
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- Synthesis and evaluation of the cytotoxicities of neoflavenes
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The synthesis of neoflavene and neoflavenes with methoxy substituents at different positions are described. As starting materials, various salicylaldehydes were run through sequential reactions such as O-allylation, Grignard reaction, oxidation, Wittig reaction, and ring-closing metathesis to yield the target neoflavenes in good yield. Among the prepared neoflavenes, 7-methoxy-4′-methoxyneoflavene (6e) and 8-methoxy-4′- methoxyneoflavene (6f) exhibiting potential cell toxicities against various cells were disclosed. In particular, 6f which exhibited an IC50 value of 6.5 ± 2.0 and 5.1 ± 1.1 μM against gastric carcinoma and lung carcinoma cells in vitro was found, respectively. Meanwhile, the structure and activity relationship of our synthesized neoflavenes is further discussed briefly.
- Li, Sie-Rong,Chen, Hsing-Ming,Chen, Po-Yuan,Tsai, Jui-Chi,Chen, Liang-Yeu,Wang, Eng-Chi,Huang, Yi-Ting,Wei, Yun-Chen,Lu, Pei-Jung
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experimental part
p. 923 - 932
(2009/12/08)
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- INTRAMOLECULAR ENE REACTION ON UNSATURATED THIOKETONES
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The thermal cyclization of o-(2-substituted allyloxy)thiobenzophenones giving 1,5-oxathiocine derivatives is reported.This is the first example of the new type intramolecular ene reaction of unsaturated thioketones.
- Motoki, Shinichi,Watanabe, Tsumoru,Saito, Takao
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p. 189 - 192
(2007/10/02)
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