- H2S-Scavenged and Activated Iron Oxide-Hydroxide Nanospindles for MRI-Guided Photothermal Therapy and Ferroptosis in Colon Cancer
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Overproduced hydrogen sulfide (H2S) is of vital importance for the progress of colon cancer and promotes cancer cellular proliferation. Devising pharmacological nanomaterials for tumor-specific H2S activation will be significant for precise colon cancer treatment. Herein, a biocompatible fusiform iron oxide-hydroxide nanospindles (FeOOH NSs) nanosystem for magnetic resonance imaging (MRI), ferroptosis, and H2S based cascade reaction-enhanced combinational colon cancer treatment is developed. The FeOOH NSs can effectively scavenge endogenous H2S via the reduction reaction to prohibit the growth of CT26 colon cancer. The cascade produced FeS driven by overexpressed H2S exhibits near-infrared-triggered photothermal therapy capability and Fe2+-mediated ferroptosis functionality. Meanwhile, the as-prepared FeOOH NSs can light up tumor tissues as a potent MRI contrast agent. Additionally, FeOOH NSs present desirable biosafety in a murine model for up to three months and avoid any long-term toxicity. Furthermore, it is found that these H2S-responsible nanotheranostics do not cause any cure effects on other cancer types, such as 4T1 breast cancer. Overall, the findings illustrate that the biocompatible FeOOH NSs can be successfully employed as a theranostic for specifically treating colon cancer, which may promote the clinical translation and development of H2S-responsive nanoplatforms.
- Li, Yangyang,Chen, Weiyu,Qi, Yuchen,Wang, Shuai,Li, Lei,Li, Wanlin,Xie, Tingting,Zhu, Huanle,Tang, Zhe,Zhou, Min
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- Confirmation of the assignment of vibrations of goethite: An ATR and IES study of goethite structure
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(Graph Presented) Transmission electron microscopy (TEM), field emission scanning electron microscopy (FE-SEM/EDS) and X-ray diffraction (XRD) were used to characterize the morphology of synthetic goethite. The behavior of the hydroxyl/water molecular units of goethite and its thermally treated products were characterized using Fourier transform-infrared emission spectroscopy (FT-IES) and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy. The results showed that all the expected vibrational bands between 4000 and 650 cm-1 including the resolved bands (3800-2200 cm -1) were confirmed. A band attributed to a new type of hydroxyl unit was found at 3708 cm-1 and assigned to the FeO-H stretching vibration without hydrogen bonding. This hydroxyl unit was retained up to the thermal treatment temperature of 500°C. On the whole, seven kinds of hydroxyl units, involving three surface hydroxyls, a bulk hydroxyl, a FeO-H without hydrogen bonding, a nonstoichiometric hydroxyl and a reversed hydroxyl were observed, and three kinds of adsorbed water were found in/on goethite.
- Liu, Haibo,Chen, Tianhu,Qing, Chengsong,Xie, Qiaoqin,Frost, Ray L.
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- Magnetic tuning of plasmonic excitation of gold nanorods
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By using gold nanorods as an example, we report the dynamic and reversible tuning of the plasmonic property of anisotropically shaped colloidal metal nanostructures by controlling their orientation using external magnetic fields. The magnetic orientationa
- Wang, Mingsheng,Gao, Chuanbo,He, Le,Lu, Qipeng,Zhang, Jinzhong,Tang, Chi,Zorba, Serkan,Yin, Yadong
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- Synthesis, crystal, and magnetic structures of the sodium ferrate (IV) Na4FeO4 studied by neutron diffraction and Moessbauer techniques
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The alkali sodium ferrate (IV) Na4FeO4 has been prepared by solid-state reaction of sodium peroxide Na2O2 and wustite Fe1-xO, in a molar ratio Na/Fe=4, at 400°C under vacuum. Powder X-ray and neutron diffraction studies indicate that Na4FeO4 crystallizes in the triclinic system P-1 with the cell parameters: a=8.4810(2) A, b=5.7688(1) A, c=6.5622(1) A, α=124.662(2)°, β=98.848(2)°, γ=101.761(2)° and Z=2. Na4FeO4 is isotypic with the other known phases Na4MO4 (M=Ti, Cr, Mn, Co and Ge, Sn, Pb). The solid solution Na4FexCo1-xO4 exists for x=0-1 and we have followed the evolution of the cell parameters with x to determine the lattice parameters of the triclinic cell of Na4FeO4. A three-dimensional network of isolated FeO4 tetrahedra connected by Na atoms characterizes the structure. This compound is antiferromagnetic below TN=16 K. At 2 K the magnetic cell is twice the nuclear cell and the magnetic structure is collinear (μFe=3.36(12) μB at 2 K). This black compound is highly hygroscopic. In water or on contact with the atmospheric moisture it is disproportionated in Fe3+ and Fe6+. The Moessbauer spectra of Na4FeO4 are fitted with one doublet (δ=-0.22 mm/s, Δ=0.41 mm/s at 295 K) in the paramagnetic state and with a sextet at 8 K. These parameters characterize Fe4+ highspin in tetrahedral FeO4 coordination.
- Jeannot,Malaman,Gerardin,Oulladiaf
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- Controlled synthesis of α-FeOOH nanorods and their transformation to mesoporous α-Fe2O3, Fe3O4@C nanorods as anodes for lithium ion batteries
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α-FeOOH nanorods with varying lengths of 200-500 nm and axis ratios of 2-8 have been successfully synthesized by a simple hydrothermal method with different amounts of hydrazine. Hierarchical nanostructured mesoporous α-Fe2O3 and Fe3O4@C, which combined both mesoporosity and carbon coating, were fabricated by transformation of these α-FeOOH nanorods. The mechanism of formation has been described in detail. The α-FeOOH, mesoporous α-Fe2O3 and Fe3O4@C samples with the longest nanorods exhibited excellent cycle and rate performance, as the long nanorods could ensure many fast and convenient electron transport pathways, thus enhancing the electronic conductivity. The as-synthesized mesoporous α-Fe2O3 and Fe3O4@C nanorods showed large specific surface area and porosity due to the inner mesoporous structure, effectively increasing the contact area between the electrode materials and electrolyte, shortening the diffusion length of Li+ and alleviating the stress from volume changes during the charge-discharge process. Mesoporous Fe3O 4@C nanorods exhibit high reversible capacities of 1072 mAh g -1 after 50 cycles, demonstrating the superior electron transport and fast Li+ diffusion ability combination of outer carbon layer and mesoporous microstructure. The Royal Society of Chemistry 2013.
- Wang, Jin,Li, Linlin,Wong, Chui Ling,Sun, Linfeng,Shen, Zexiang,Madhavi, Srinivasan
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- Influence of metal ions on the transformation of γ-FeOOH into α-FeOOH
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The transformation of γ-FeOOH into α-FeOOH in FeSO4 solutions at 50°C was investigated in two different ways by dissolving Ti(IV), Cr(III), Cu(II), Ni(II), and Mn(II) in the solutions at atomic ratios of metal/Fe of 0-0.1 and adding these metal ions to th
- Ishikawa, Tatsuo,Minamigawa, Megumi,Kandori, Kazuhiko,Nakayama, Takenori,Tsubota, Takayuki
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- Facile Access to an Active γ-NiOOH Electrocatalyst for Durable Water Oxidation Derived From an Intermetallic Nickel Germanide Precursor
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Identifying novel classes of precatalysts for the oxygen evolution reaction (OER by water oxidation) with enhanced catalytic activity and stability is a key strategy to enable chemical energy conversion. The vast chemical space of intermetallic phases offers plenty of opportunities to discover OER electrocatalysts with improved performance. Herein we report intermetallic nickel germanide (NiGe) acting as a superior activity and durable Ni-based electro(pre)catalyst for OER. It is produced from a molecular bis(germylene)-Ni precursor. The ultra-small NiGe nanocrystals deposited on both nickel foam and fluorinated tin oxide (FTO) electrodes showed lower overpotentials and a durability of over three weeks (505 h) in comparison to the state-of-the-art Ni-, Co-, Fe-, and benchmark NiFe-based electrocatalysts under identical alkaline OER conditions. In contrast to other Ni-based intermetallic precatalysts under alkaline OER conditions, an unexpected electroconversion of NiGe into γ-NiIIIOOH with intercalated OH?/CO32? transpired that served as a highly active structure as shown by various ex situ methods and quasi in situ Raman spectroscopy.
- Menezes, Prashanth W.,Yao, Shenglai,Beltrán-Suito, Rodrigo,Hausmann, J. Niklas,Menezes, Pramod V.,Driess, Matthias
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supporting information
p. 4640 - 4647
(2021/02/05)
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- New method for preparing imatinib intermediate
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The invention discloses a new method for preparing an imatinib intermediate N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine. The method comprises the following steps: stirring, refluxing and reacting FeCl3.6H2O and sodium hydroxide in an aqueous solution with the pH value of 7.0-8.0 at 100DEG C for 12, carrying out pumping filtration, drying the obtained solid in an oven to obtain a required catalyst FeO(OH), and reducing a nitro group in N-(5-nitro-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine with FeO(OH) as a catalyst and hydrazine hydrate as a reducing agent to generate N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine. The method for preparing N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine has the advantages of easily available raw materials, simple operation, high total yield of the above reaction, and is a synthesis route suitable for industrially producing N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine.
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Paragraph 0009
(2016/11/21)
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- Goethite nanorods as a cheap and effective filler for siloxane nanocomposite elastomers
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Iron oxide (goethite) with a nanorod morphology was prepared by a chemical precipitation method and characterized by FTIR, EDX, TEM, WAXD. This was used as an active filler to prepare dielectric elastomer nanocomposites by its incorporation, besides silica, in a silicone matrix consisting in a high molecular weight polydimethylsiloxane-α,ω-diol (PDMS). The nanocomposites were processed as films, stabilized by peroxidic crosslinking at high temperature, and their properties of interest for potential use in the structure of electromechanical devices were studied. It is for the first time that such composites, based on PDMS and iron oxide in a well-defined type (goethite) and shape (nanorods) are approached from the perspective of dielectric elastomers. The introduction of iron oxide nanoparticles into the polymer matrix resulted in improvements in both mechanical and dielectric properties. Thus the breaking strain and the dielectric constant values increased in comparison with those of the pure polymer sample, while the dielectric loss preserved low values specific for dielectrics. This journal is
- Iacob,Stiubianu,Tugui,Ursu,Ignat,Turta,Cazacu
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p. 45439 - 45445
(2015/06/02)
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- Aqueous composition containing high purity iron oxide
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An aqueous composition comprising water and high purity iron oxide preferably including a preservative is described. The composition is useful as a coloration ingredient in pharmaceuticals, cosmetics, foods, pet foods, and tobacco products which can be incorporated as a liquid conveniently into system of customers that desire a liquid high purity iron oxide ingredient or have been convinced to change from a dry high purity iron oxide ingredient to obtain the benefits of a liquid system.
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