- PROCESS FOR PREPARING TEMOZOLOMIDE
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The present invention relates to a process for preparing temozolomide.
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Page/Page column 4
(2008/06/13)
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- Contra-thermodynamic trans-esteripication of carbamates by counter-attack strategy: A viable non-phosgene, non-mic route to carbamate pesticides
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Treatment of methyl N-methylcarbaaate (1, R= Me) with phosphorus oxychloride and 1-naphthol results in the formation of the transesterified product, 1-naphthyl N-methylcarbamate (2, Ar=1-naphthy 1) in good yield. Similarly, ethyl N-methylthiocarbamate (5) is converted to 1-naphthyl N-methylcarbamate (2, Ar= 1-naphthyl) on treatment with phosphorus oxychloride and 1-naphthol. The mechanism of these interesting and industrially important transformations is discussed.
- Kulkarni,Naik,Tandel,Rajappa
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p. 1249 - 1256
(2007/10/02)
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- Process for the preparation of N,N-diaryl-ureas
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N,N-Diaryl-ureas of the formula wherein R1 and R2 denote aryl and R3 denotes alkyl, aralkyl or aryl, can be prepared by a process in which a diarylamine of the formula is reacted with an isocyanate of the formula wherein R1, R2 and R34 have the above meaning, in the presence of acid compounds and in the presence or absence of an inert solvent and/or diluent at elevated temperature.
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- Method of treating the symptoms of senile cognitive decline employing di- or trisubstituted urea cholinergic agents
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Certain trisubstituted alkyl, aryl, pyridinyl, piperidinyl, and piperazinyl urea compounds stimulate the release of acetylcholine and are thus useful agents for the treatment of senile cognitive decline characterized by decreased cerebral acetylcholine production or release. A method for treating the symptoms of senile cognitive decline is disclosed.
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