- Homo- and hetero-[3]rotaxanes with two π-systems clasped in a single macrocycle
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Here we present the first synthesis of a [3]rotaxane with two dumbbell components threaded through a single γ-cyclodextrin macrocycle. This synthesis is carried out in two steps: first one dumbbell is synthesized threaded through the macrocycle to give a
- Klotz, Eric J. F.,Claridge, Tim D. W.,Anderson, Harry L.
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Read Online
- Bistetrazine-Cyanines as Double-Clicking Fluorogenic Two-Point Binder or Crosslinker Probes
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Fluorogenic probes can be used to minimize the background fluorescence of unreacted and nonspecifically adsorbed reagents. The preceding years have brought substantial developments in the design and synthesis of bioorthogonally applicable fluorogenic syst
- Kormos, Attila,Koehler, Christine,Fodor, Eszter A.,Rutkai, Zsófia R.,Martin, Madison E.,Mez?, Gábor,Lemke, Edward A.,Kele, Péter
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- Smart J-aggregate of cyanine photosensitizer with the ability to target tumor and enhance photodynamic therapy efficacy
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Photodynamic therapy (PDT) has been demonstrated to be effective for cancer treatment. Design of photosensitizers (PS) featuring tumor targeting, long excitation wavelengths, and high singlet oxygen quantum yields (Φ(1O2)) is the cru
- Li, Miao,Sun, Wen,Tian, Ruisong,Cao, Jianfang,Tian, Ye,Gurram, Bhaskar,Fan, Jiangli,Peng, Xiaojun
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- Studies on a vinyl ruthenium-modified squaraine dye: Multiple visible/near-infrared absorbance switching through dye- and substituent-based redox processes
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The bis(vinyl ruthenium)-modified squaraine dye 1 was synthesized by treatment of [RuHCl(CO)(PiPr3)2] with bis(ethynyl)- substituted squaraine 8. Spectroscopic and electrochemical measurements on 1 and its organic precursors 6-8 were
- Chen, Jing,Winter, Rainer F.
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- Hypoxia-activated NIR photosensitizer anchoring in the mitochondria for photodynamic therapy
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Photodynamic therapy is considered as a promising treatment for cancer, but still faces several challenges. The hypoxic environment in solid tumors, imprecise tumor recognition and the lack of selectivity between normal and cancer cells extremely hinder t
- Xu, Feng,Li, Haidong,Yao, Qichao,Ge, Haoying,Fan, Jiangli,Sun, Wen,Wang, Jingyun,Peng, Xiaojun
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- Iodinated xanthene-cyanine NIR dyes as potential photosensitizers for antimicrobial photodynamic therapy
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Photosensitizers (PSs) are chemical entities that upon light exposure are able to produce cytotoxic species such as singlet oxygen superoxide and free radicals. PSs are used in photodynamic therapy applications (PDT) to eradicate cancer cells, pathogenic bacteria, fungi, and viruses. Development of the NIR-activatable photosensitizes with high phototoxicity and low toxicity in dark conditions is challenging. Here we first report on the synthesis and antimicrobial testing of the new NIR photosensitizers based on the iodinated xanthene-cyanine dyes. These new photosensitizers exhibit high antimicrobial efficacy on Staphylococcus aureus pathogens at low dye concentration (~0.5 μM) and low NIR light dose (24.3 J/cm2).
- Ebaston, T. M.,Gellerman, Gary,Nakonechny, Faina,Patsenker, Leonid,Talalai, Efrosiniia
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- Photodynamic therapy with tumor cell discrimination through rna-targeting ability of photosensitizer
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Photodynamic therapy (PDT) represents an effective treatment to cure cancer. The targeting ability of the photosensitizer is of utmost importance. Photosensitizers that discriminate cancer cells can avoid the killing of normal cells and improve PDT effica
- Jin, Xiaoyi,Li, Miao,Ma, Xiuqin,Tan, Yang,Tian, Ye,Xu, Yuan
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supporting information
(2021/10/12)
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- Bioorthogonally Applicable Fluorogenic Cyanine-Tetrazines for No-Wash Super-Resolution Imaging
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The synthesis, fluorogenic characterization, and labeling application of four tetrazine-quenched cyanine probes with emission maxima in the red-far red range is reported. Fluorescence of the cyanine-cores is quenched via through-bond-energy-transfer (TBET) exerted by a bioorthogonal tetrazine unit. Upon bioorthogonal labeling reaction with cyclooctyne tagged proteins, the quenching effect ceases, and thus the fluorescence reinstates, resulting in an increase in fluorescence intensity. As a rare example among indocyanines, one of our new probes was found suitable in STED-based super-resolution imaging. The applicability of this fluorogenic Tet-Cy3 probe was therefore further demonstrated in the bioorthogonal labeling of cytoskeletal protein, actin, with subsequent super-resolution microscopy (STED) imaging even under no-wash conditions.
- Knorr, Gergely,Kozma, Eszter,Schaart, Judith M.,Németh, Krisztina,T?r?k, Gy?rgy,Kele, Péter
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p. 1312 - 1318
(2018/04/23)
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- Iodinated cyanine dyes: a new class of sensitisers for use in NIR activated photodynamic therapy (PDT)
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A new class of iodinated cyanine dyes have been prepared for use in NIR excited photodynamic therapy (PDT) and demonstrated improved efficacy in two pancreatic cell lines as well as excellent tumour control in a murine model of the disease.
- Atchison, Jordan,Kamila, Sukanta,Nesbitt, Heather,Logan, Kieran A.,Nicholas, Dean M,Fowley, Colin,Davis, James,Callan, Bridgeen,McHale, Anthony P,Callan, John F
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supporting information
p. 2009 - 2012
(2017/02/15)
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- MICROBUBBLE-CHEMOTHERAPEUTIC AGENT COMPLEX FOR SONODYNAMIC THERAPY
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The invention relates to methods of sonodynamic therapy comprising the co-administration of a microbubble-chemotherapeutic agent complex together with a microbubble-sonosensitiser complex. It further relates to pharmaceutical compositions comprising these
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Page/Page column 54; 55
(2017/06/29)
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- Photoinduced cleavage of N-N bonds of aromatic hydrazines and hydrazides by visible light
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A photocatalytic system involving [Ru(bpyrz)(PFH, visible light, and air has been developed for cleavage of the N-N bonds of hydrazines and hydrazides. This catalytic system is generally effective for N,N-disubstituted hydrazine and hydrazide derivatives, including arylhydrazides, N-alkyl-N-arylhydrazines, and N,N-diarylhydrazines. The utility of this cleavage reaction has been demonstrated by synthesizing a variety of secondary aromatic amines. Georg Thieme Verlag Stuttgart ? New York.
- Zhu, Mingzhao,Zheng, Nan
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p. 2223 - 2236
(2011/09/15)
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- Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles
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Compounds are provided having the capability of binding therapeutically active substances to lipid containing bio-compatible particles, such as cells or viruses. These compounds include a bio-affecting moiety, comprising a therapeutically active substance
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