- Azabicyclo derivatives, preparation methods thereof, and pharmaceutical applications thereof
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The invention relates to azabicyclo derivatives, preparation methods thereof, and pharmaceutical applications thereof. Specifically, the invention discloses compounds represented by a formula (I), or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs thereof. The invention also provides preparation methods of the derivatives, and applications of the derivatives in EGFR inhibitors. The definitions of the groups in the formula are defined in the specifications.
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- Discovery and process synthesis of novel 2,7-pyrrolo[2,1- f ][1,2,4]triazines
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The synthesis of a new kinase inhibitor template 2-anilino-7-aryl- pyrrolo[2,1-f][1,2,4]triazine is described which includes a late stage orthogonally reactive key intermediate amenable to rapid diversification as well an optimized in situ triflate displa
- Thieu, Tho,Sclafani, Joseph A.,Levy, Daniel V.,McLean, Andrew,Breslin, Henry J.,Ott, Gregory R.,Bakale, Roger P.,Dorsey, Bruce D.
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p. 4204 - 4207
(2011/10/04)
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