Synthesis of C3′ modified nucleosides for selective generation of the C3′-deoxy-3′-thymidinyl radical: A proposed intermediate in LEE induced DNA damage
DNA damage pathways induced by low-energy electrons (LEEs) are believed to involve the formation of 2-deoxyribose radicals. These radicals, formed at the C3′ and C5′ positions of nucleotides, are the result of cleavage of the C-O phosphodiester bond throu
Audat, Suaad A. S.,Trzasko Love, Cherylann,Al-Oudat, Buthina A. S.,Bryant-Friedrich, Amanda C.
p. 3829 - 3837
(2012/06/29)
Action of nucleophiles on 2,3'-anhydrothymidine: Side-reactions involving the possible intermediacy of 2,5'-anhydro-1-(2-deoxy-β-D-threo-pentofuranosyl)thymine
2,3'-Anhydrothymidine (1) reacts with the sodium salt of propane-2-thiol and with sodium phenyl selenide to give 5'-substituted products [(3b) and (3c), respectively] in addition to the expected 3'-substituted 2',3'-dideoxynucleoside derivatives [(2b) and
Joshi,Reese
p. 2371 - 2374
(2007/10/02)
Selenium nucleophiles for the preparation of antiviral nucleosides
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Cosford,Schinazi
p. 2161 - 2165
(2007/10/02)
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