- Ynol Ethers as Ketene Equivalents in Rhodium-Catalyzed Intermolecular [5 + 2] Cycloaddition Reactions
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The previously unexplored metal-catalyzed [5 + 2] cycloadditions of vinylcyclopropanes (VCPs) and electron-rich alkynes (ynol ethers) have been found to provide a highly efficient, direct route to dioxygenated seven-membered rings, a common feature of num
- Wender, Paul A.,Ebner, Christian,Fennell, Brandon D.,Inagaki, Fuyuhiko,Schr?der, Birte
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- Highly Site Selective Formal [5+2] and [4+2] Annulations of Isoxazoles with Heterosubstituted Alkynes by Platinum Catalysis: Rapid Access to Functionalized 1,3-Oxazepines and 2,5-Dihydropyridines
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Platinum-catalyzed formal [5+2] and [4+2] annulations of isoxazoles with heterosubstituted alkynes enabled the atom-economical synthesis of valuable 1,3-oxazepines and 2,5-dihydropyridines, respectively. Importantly, this Pt catalysis not only led to unique reactivity dramatically divergent from that observed under Au catalysis, but also proceeded via unprecedented α-imino platinum carbene intermediates.
- Shen, Wen-Bo,Xiao, Xin-Yu,Sun, Qing,Zhou, Bo,Zhu, Xin-Qi,Yan, Juan-Zhu,Lu, Xin,Ye, Long-Wu
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supporting information
p. 605 - 609
(2017/01/07)
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