- Method for synthesizing (Z)-3-halogenated-2-(4-fluorophenyl)-1-(2-chlorphenyl) propylene
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The invention discloses a method for synthesizing (Z)-3-halogenated-2-(4-fluorophenyl)-1- (2-chlorphenyl) propylene. The method comprises the following steps: mixing a raw material 1-halogenated-3-(2-chlorobenzene)-2- (4-fluorobenzene)-2-propanol with an organic solvent to obtain a material A, mixing an acid catalyst, acid anhydride and the organic solvent to obtain a material B, pumping the temperature-controlled material A and the temperature-controlled material B into a mixer by using a liquid conveying pump at the same time, and uniformly mixing the materials by using the mixer, feeding the mixture into a micro-channel reactor for reaction, stably maintaining the reaction at -20-60 DEG C for 15-550 seconds, collecting reaction liquid at the tail end of the reactor, and performing aftertreatment to obtain (Z)-3-halogenated-2- (4-fluorophenyl)-1-(2-chlorphenyl) propylene with the yield of 50-85 percent. The configuration selectivity of (Z)/(E) 3chloro2 (4fluorophenyl) 1 (2chlorphenyl) propylene in the method is as high as 11.4: 1, and the method has the advantages of high selectivity, simplicity and convenience in operation, good safety, high yield and the like, and is suitable for industrial production.
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Paragraph 0020-0022; 0024-0029
(2021/04/17)
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- Stereoselective preparation of Z-1,2-diarylallyl chlorides and the conversion thereof into azolylmethyloxiranes, and novel intermediates
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The preparation of Z-1,2-diarylallyl chlorides of the general formula I STR1 in which R1 and R2, independently of one another, are hydrogen, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy or a substituted aromatic radical, and n and m are 1, 2 or 3, by dehydrating chlorohydrins of the formula II STR2 in which the radicals are as defined above, at up to 50° C. in an inert ether or carboxylic acid ester as solvent and in the presence of a carboxylic anhydride and an organic or inorganic acid, the conversion thereof into azolylmethyloxiranes, and novel intermediates are described.
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