cas 133645-46-2, 3S)-Hydroxy Simvastatin | Articles data ｜lookchem

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133645-46-2

Articles about 133645-46-2Total 3 be found

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COMPOUND, AND SEPARATION METHOD, SYNTHESIS METHOD AND USE THEREOF
The invention relates to new compounds as well as a separation method, a synthetic method and use thereof. It is demonstrated by an assay on activity that the compound has an activity of inhibiting an HMG-CoA reductase. In addition, the invention also relates to a derivative of the compound.
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Paragraph 0178-0179

(2018/02/28)

Reactivity of Hydroxymethylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors Containing Conjugated Dienes with Phenolic Antioxidants in the Solid-State
The object of this invention was to probe the reactivity of lovastatin, simvastatin, pravastatin, and mevastatin in the solid-state without radical initiators in order to determine the antioxidant that provided the best stability for the statin. Phenolic antioxidants were evaluated.
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Page/Page column 2-4

(2009/01/24)

Autooxidation of simvastatin
Autooxidation of the cholesterol-lowering agent simvastatin in ethylene dichloride solution with an azo-type free-radical initiator was investigated in kinetic studies using HPLC. The primary products were oligomers, with peroxide groups within the backbone chain, and some monomeric epoxides. These and several secondary products were isolated chromatographically and identified spectroscopically. A reaction scheme was proposed in which the oligomers arise from competitive hydrogen abstraction and addition reactions of oligomeric free radicals with simvastatin while the epoxides arise from homolytic peroxide cleavage.
Smith,DiMichele,Colwell Jr.,Dezeny,Douglas,Reamer,Verhoeven
p. 4447 - 4462
(2007/10/02)

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Chemical Properties

Solubility:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere
Refractive Index: 1.542
PSA: 93.06000
LogP: 3.70050

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