Enantioselective copper-catalyzed alkynylation of benzopyranyl oxocarbenium ions
We have developed highly enantioselective, copper-catalyzed alkynylations of benzopyranyl acetals. By using a copper(I) catalyst equipped with a chiral bis(oxazoline) ligand, high yields and enantioselectivities are achieved in the alkynylation of widely
Srinivas, Harathi D.,Maity, Prantik,Yap, Glenn P. A.,Watson, Mary P.
p. 4003 - 4016
(2015/09/07)
Copper-catalyzed enantioselective additions to oxocarbenium ions: Alkynylation of isochroman acetals
We have developed an enantioselective, copper(I)-catalyzed addition of terminal alkynes to racemic isochroman acetals. This method is one of the first transition-metal-catalyzed approaches to enantioselective additions to prochiral oxocarbenium ions. In this reaction, TMSOTf is used to form the oxocarbenium ion in situ under conditions compatible with simultaneous formation of the chiral copper acetylide. By using a bis(oxazoline) ligand, good yields and enantioselectivities are observed for a variety of enantioenriched 1-alkynyl isochromans.
Maity, Prantik,Srinivas, Harathi D.,Watson, Mary P.
p. 17142 - 17145
(2011/12/13)
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