- N-dealkylative SNAr reaction using aromatic halides: Synthesis of dihydrobenzoxazine and tetrahydrobenzoxazepine derivatives
-
An efficient protocol for the synthesis of dihydrobenzoxazine and tetrahydrobenzoxazepine derivatives has been developed using haloarenes involving N-dealkylative SNAr reaction. The method employs a wide variety of substrates and features the f
- Pathan, Mosim Amin,Khan, Faiz Ahmed
-
-
Read Online
- Synthesis and antibacterial activities of marine natural product ianthelliformisamines and subereamine synthetic analogues
-
Marine sponges of the genus Suberea produce variety of brominated tyrosine alkaloids which display diverse range of biological activities including antiproliferative, antimicrobial and antimalarial activities. In continuation of our search for biologicall
- Anindya, Roy,Jena, Tapan Kumar,Karamathulla, Shaik,Khadake, Shivaji Narayan,Khan, Faiz Ahmed,Monisha, Mohan,Tuti, Nikhil Kumar
-
-
- N1,N1-dimethyl-N3-(3-(trifluoromethyl) phenethyl)propane-1,3-diamine, a new lead for the treatment of human African trypanosomiasis
-
The natural product, convolutamine I (1), has anti-trypanosomal activity however it has a high molecular weight of 473 due to a presence of 3 bromine atoms. The synthesis of the natural product convolutamine I (1) together with its analogues are presented. A SAR study against Trypanosoma brucei brucei led to compounds with improved physico-chemical properties: lower molecular weight and lower log P while maintaining potency (with a slight 2-fold improvement).
- Pham, Ngoc B.,Deydier, Sophie,Labaied, Mehdi,Monnerat, Severine,Stuart, Kenneth,Quinn, Ronald J.
-
p. 541 - 551
(2014/03/21)
-
- Cu(I)-catalyzed intramolecular cyclization of ene-carbamates: Synthesis of indoles and pyrrolo[2,3-c]pyridines
-
Over the past few years, the use of palladium-catalyzed aromatic carbon-nitrogen bond forming reactions by the cross-coupling of aryl halides or triflates and amines has become a useful synthetic tool. Herein, we describe a copper(I) catalyst system that allows efficient synthesis of functionalized indoles and pyrrolo[2,3-c]pyridines. This method takes advantage of amino acid promoted copper coupling of amines with aryl halides, in particular, the use of the CuI/l-proline catalyst system.
- Barberis, Claude,Gordon, Thomas D.,Thomas, Christine,Zhang, Xiaolei,Cusack, Kevin P.
-
p. 8877 - 8880
(2007/10/03)
-
- Asymmetric synthesis of amathamides A and B: Novel alkaloids isolated from Amathia wilsoni
-
Syntheses of the amathamides A and B ((2S)-N-[(E and Z)-2(2,4-dibromo-5-methoxyphenylethenyl]-1-methyl-2-pyrrolinecarboxamides), new alkaloids isolated from the Tasmanian marine bryozoan Amathia wilsoni, were accomplished by a sequence of reactions starting from 3-hydroxybenzaldehyde.
- Ramirez Osuna, Moises,Aguirre, Gerardo,Somanathan, Ratnasamy,Molins, Elias
-
p. 2261 - 2266
(2007/10/03)
-