Direct, nucleophilic radiosynthesis of [18F]trifluoroalkyl tosylates: Improved labelling procedures
A rapid and efficient protocol to afford the title compound 2-[ 18F]-fluoro-2,2-difluoroethyl tosylate ([18F]7b) is described. Starting from [18F]fluoride ion, labelling reagent 7b was obtained in good yields and a high specific radioactivity. Compound ([ 18F]7b) was then used to synthesise a prospective radiotracer for PET-imaging in dementia.
Riss, Patrick J.,Ferrari, Valentina,Brichard, Laurent,Burke, Paul,Smith, Robert,Aigbirhio, Franklin I.
p. 6980 - 6986,7
(2012/12/12)
A simple, rapid procedure for nucleophilic radiosynthesis of aliphatic [18F]trifluoromethyl groups
A procedure for the radiosynthesis of aliphatic [18F] trifluoromethyl groups by reacting 1,1-difluorovinyl precursors with [ 18F]fluoride ions, resulting in the equivalent of direct nucleophilic addition of H[18F]F, has been developed. A variety of 18F-labelled model compounds were then obtained and two potential [18F]radiotracers were synthesised by a two step process starting from 1,1-difluorovin-2-yl 4-toluenesulfonate. The method is widely applicable for the synthesis of novel radiotracers in high radiochemical yields and good specific activity.
Riss, Patrick J.,Aigbirhio, Franklin I.
supporting information; experimental part
p. 11873 - 11875
(2011/12/04)
More Articles about upstream products of 1350432-91-5