- 2,3-DIHYDRO-1H-PYRROLIZINE-7-FORMAMIDE DERIVATIVE AND APPLICATION THEREOF
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The present application relates to a 2,3-dihydro-1H-pyrrolizine-7-formamide derivative as a nucleoprotein inhibitor and a use in preparation of a drug for treating HBV related diseases. The present application specifically relates to a compound represented by formula (II), and isomers or pharmaceutically acceptable salts thereof.
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Paragraph 0293; 0294; 0297; 0299
(2021/04/16)
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- NOVEL AMIDE AND AMIDINE DERIVATIVES AND USES THEREOF
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The present invention relates to inhibitors of 11-β-hydroxysteroid dehydrogenase type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
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Page/Page column 33
(2010/11/03)
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- GUT MICROSOMAL TRIGLYCERIDE TRANSPORT PROTEIN INHIBITORS
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Compounds represented by formula (I): are inhibitors of gut microsomal triglyceride transfer protein. Such compounds are useful in treating diseases or conditions such as diabetes and obesity, along with patients are risk for developing such diseases or conditions.
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Page/Page column 123
(2008/12/08)
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- Synthesis and structural activity relationship of 11β-HSD1 inhibitors with novel adamantane replacements
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A series of structurally novel and metabolically stable bridged bicyclic carbocycle and heterocycle adamantane replacements have been synthesized and biologically evaluated. Several of these compounds exhibit excellent human and mouse 11β-HSD1 potency and
- Yeh, Vince S.C.,Kurukulasuriya, Ravi,Madar, David,Patel, Jyoti R.,Fung, Steven,Monzon, Katina,Chiou, William,Wang, Jiahong,Jacobson, Peer,Sham, Hing L.,Link
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p. 5408 - 5413
(2007/10/03)
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