- ADENOSINE RECEPTOR ANTAGONISTS AND USES THEREOF
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Disclosed herein are compounds, compositions, formulations, and methods for modulating the A2B adenosine receptor.
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Paragraph 00361; 00362
(2019/10/01)
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- Process for preparing 1-(2-ethyl-butyl)-cyclohexanecarboxylic acid
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The present invention relates to a process for the preparation of 1-(2-ethyl-butyl)- cyclohexanecarboxylic acid which is useful as an intermediate in the preparation of pharmaceutical active compounds, wherein cyclohexanecarboxylic acid alkali metal salt reacts with an alkylating agent in the presence of a secondary amine and (C1-C6) alkyllithium, (C3-C6) cycloalkyllithium or phenyllithium.
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Page/Page column 4
(2008/12/06)
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- Preparing carboxylic acids from glycidonitriles through enol acylates
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Process for preparing carboxylic acids by converting a glycidonitrile to the enol acylate via hydrohalogenation, acylation and dehydrohalogenation procedures, and conversion of the enol acylate to the carboxylate salt with a base and of the salt to the carboxylic acid with acid. Cyanide content in the mixture is destroyed by adding persulfate or hypochlorite salts. This process, can be used, e.g., to prepare 2-(4'-isobutylphenyl)propionic acid, now known generically as ibuprofen, a highly active anti-inflammatory drug, as well as a host of other useful carboxylic acids.
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