- Aryne cycloaddition reactions of benzodioxasilines as aryne precursors generated by catalytic reductive ortho-C[sbnd]H silylation of phenols with traceless acetal directing groups
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Diversely substituted arylsilyl triflates, as aryne precursors for aryne cycloaddition reactions, were accessed from benzodioxasilines. Catalytic reductive C[sbnd]H ortho-silylation of phenols with traceless acetal directing groups was exploited to prepare benzodioxasilines. Sequential addition of MeLi and then trifluoromethanesulfonic anhydride to benzodioxasilines provided arylsilyl triflates in a single pot. Notably, this approach was successfully utilized to prepare sterically hindered 1,2,3-trisubstituted arylsilyl triflates, which ultimately underwent fluoride-mediated aryne cycloaddition.
- Asgari, Parham,Dakarapu, Udaya Sree,Nguyen, Hiep H.,Jeon, Junha
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