- Effect of ring A and ring B substitution on the cytotoxic potential of pyrazole tethered chalcones
-
Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are collectively known as chalcones. The cytotoxic potential of chalcones which consists of C6-C 3-C6 units gets enhanced by the incorporation of pyrazole ring as proved by our earlier studies. Thus in the present work, pyrazoles of chalcones with ring A substituted by furan, naphthalene and variety of substituted phenyl rings has been prepared and evaluated for in vitro cytotoxic activity against PC-3, OVCAR, IMR-32, HEP-2 human cancer cell lines. Springer Science+Business Media, LLC 2011.
- Nepali, Kunal,Kadian, Kanika,Ojha, Ritu,Dhiman, Rajni,Garg, Atul,Singh, Gagandip,Buddhiraja, Abhishek,Bedi, Preet Mohinder Singh,Dhar, Kanaya Lal
-
p. 2990 - 2997
(2012/10/29)
-
- N-Derivatisation of some 3-(2-furyl)- and 3-(2-thienyl)-5-aryl-2-pyrazolines
-
A series of twenty six N-derivatised 3-(2-furyl)- and 3-(2-thienyl)-5-arylpyrazolines of general structure 2 has been prepared by the reactions of 2 (X=O,S) with suitable reagents.The structures of the compounds have been established by elemental analyses and spectral (IR, PMR) data.
- Khalaf, Ali A.,Kabli, Reda A.,Zimaity, M. T.,Khalil, A. M.,Kaddah, A. M.,Al-Rifaie, H. A.
-
p. 1125 - 1129
(2007/10/02)
-