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136790-76-6

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Lubiprostone crystals and methods for preparing the same
This present invention relates to novel Lubiprostone crystals and methods for preparing the same. The preparation methods provided by the invention can effectively reduce or eliminate impurity in the obtained Lubiprostone crystals.
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Page/Page column 10

(2019/04/26)

POLYMORPHIC FORMS OF LUBIPROSTONE
There is provided a crystalline form of Lubiprostone, termed APO-II and methods for making APO-II. APO-II is a polymorphic form of Lubiprostone.
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(2011/08/21)

METHODS OF MAKING LUBIPROSTONE AND INTERMEDIATES THEREOF
There is provided processes for preparing Lubiprostone and intermediates thereof. Also provided are compounds, including intermediates for preparing Lubiprostone as well as compositions comprising Lubiprostone and other compounds, including intermediates for preparing Lubiprostone and other compounds. (I)
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Page/Page column 54-55

(2010/08/08)

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333963-40-9
lubiprostone

Chemical Properties

Appearance/Colour :white solid
Melting Point: 56-59 °C
Boiling Point: 548.169 °C at 760 mmHg
Flash Point:299.385 °C
Density: 1.052 g/cm³
Solubility:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Storage Temp.:-20°C Freezer
Vapor Pressure: 1.49E-13mmHg at 25°C
Refractive Index: 1.486
PKA: 4.77±0.10(Predicted)
PSA: 83.83000
LogP: 4.30990

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