cas 1373822-52-6, 4-(2-(benzylthio)-7-(2-(4-chlorophenoxy)ethyl)-6-oxo-6,7-dihydro-1Hpurin-8-yl)benzylphosphonic acid | Articles data ｜lookchem

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1373822-52-6

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Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction
The eukaryotic initiation factor 4E (eIF4E) plays a central role in the initiation of gene translation and subsequent protein synthesis by binding the 5′ terminal mRNA cap structure. We designed and synthesized a series of novel compounds that display pot
Chen, Xiaoqi,Kopecky, David J.,Mihalic, Jeff,Jeffries, Shawn,Min, Xiaoshan,Heath, Julie,Deignan, Jeff,Lai, Sujen,Fu, Zice,Guimaraes, Cristiano,Shen, Shanling,Li, Shyun,Johnstone, Sheree,Thibault, Stephen,Xu, Haoda,Cardozo, Mario,Shen, Wang,Walker, Nigel,Kayser, Frank,Wang, Zhulun
p. 3837 - 3851
(2012/07/28)

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1373822-44-6
(4-(7-(2-(4-chlorophenoxy)ethyl)-2-(methylamino)-6-oxo-6,7-dihydro-1H-purin-8-yl)benzyl)phosphonic acid

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