Novel process for the production of 4,6-dimethyl-7-hydroxynonan-3-one
A process for the production of 4,6-dimethyl-7-hydroxynonan-3-one of specific stereochemistry is disclosed. The process results in an active (+)-serricornin.
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(2008/06/13)
THE REACTION OF TRICHLOROSILANE WITH ENAMINES
A previously unknown reaction of trichlorosilane with enamines has been discovered and a preliminary study done on the possible mechanism.The products of the reaction are a regiospecific trichlorosilyl adduct resulting from addition of the trichlorosilane to the enamine unsaturation and the amine corresponding to simple reduction of the double bond.The addition of the trichlorosilane requires no catalyst and the relative percentages of the products varies in a generally inverse fashion depending on the exact structure of the enamine.Evidence is given to support the assigned structure of the trichlorosilyl species and mechanisms are hypothesized to explain the formation of both products from a common intermediate.Steric rather than electronic factors are suggested as responsible for the observed balance between them.
Snyder, Dudley C.
p. 137 - 144
(2007/10/02)
Optimum Conditions for Enamine Synthesis by an Improved Titanium Tetrachloride Procedure
A modified procedure for enamine synthesis which results in shorter times and increased yield has been developed.Optimum conditions for the synthesis have been obtained from a series of eight different acyclic ketones with three different amines.The optimum conditions were determined either by response surface methodologgy or by simplex technique.In view of the results some consideration of the mechanism is briefly discussed.
Carlson, Rolf,Nilsson, Asa,Stroemqvist, Mats
p. 7 - 14
(2007/10/02)
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