Palladium-catalyzed double carbonylation using near stoichiometric carbon monoxide: Expedient access to substituted 13C2-labeled phenethylamines
A novel and general approach for 13C2- and 2H-labeled phenethylamine derivatives has been developed, based on a highly convergent single-step assembly of the carbon skeleton. The efficient incorporation of two carbon-13 isotopes into phenethylamines was accomplished using a palladium-catalyzed double carbonylation of aryl iodides with near stoichiometric carbon monoxide.
Nielsen, Dennis U.,Neumann, Karoline,Taaning, Rolf H.,Lindhardt, Anders T.,Modvig, Amalie,Skrydstrup, Troels
p. 6155 - 6165
(2012/09/21)
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