- A convenient synthetic methodology for the elaboration of the pyrido[2,3-b]- or [3,4-b]-pyrazine and [1,4]diazepine skeletons
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The condensation of the anion of 3-(formylamino)-2-chloropyridines, 3-(acetylamino)-2-chloro-, -4-chloro- or -2,4-dichloropyridines with various chloro-N,N-dimethylalkylamines gives rise efficiently to 1,2,3,4-tetrahydropyrido[2,3-b]- or [3,4-b]pyrazines and to 2,3,4,5-tetrahydro-1H-pyrido[2,3-b]- or [3,4-b][1,4]diazepines.
- Couture,Grandclaudon
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p. 982 - 984
(2007/10/02)
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