- Optically active 1-phenyl-2-substituted propane derivatives and methods of producing the same
-
An (S)-1-phenyl-2-substituted propane derivative shown by the following formula (I) STR1 wherein R1 and R2 represent a lower alkyl group, etc., or R1 and R2 may form together an alkylene group, etc.; R3, R4 and R5 represent a hydrogen atom, etc.; and X represents a hydroxyl group which may be protected with a protective group, or a halogen atom etc., can readily be produced (i) by permitting a microorganism belonging to the genus Torulaspora, the genus Candida, the genus Pichia or the like to act on a phenylacetone derivative and asymmetrically reducing the compound, or (ii) by sterically inverting an (R)-enantiomer. (R,R)-1-phenyl-2-[(2-phenyl-1-methylethyl)amino]ethanol derivative having a high optical purity can easily be obtained from the compound of the formula (I). The ethanol derivative is useful as an anti-obesity agent and the like.
- -
-
-
- Method of increasing lean meat in edible animals
-
The present invention discloses substituted 1,3-benzodioxoles which possess anti-diabetic and/or anti-hyperglycemic and/or anti-obesity properties in humans and other animals.
- -
-
-
- Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles
-
The present invention discloses substituted 1,3-benzodioxoles which possess anti-diabetic and/or anti-hyperglycemic and/or anti-obesity properties in humans and other animals.
- -
-
-
- Secondary amines
-
Compounds of formula (II): STR1 or salt thereof; wherein R1 is hydrogen or methyl, R2 is hydrogen or methyl, R3 is hydrogen, C1-12 straight or branched alkyl, C3-10 cycloalkyl, phenyl(C1-4)-alkyl or benzyl optionally substituted by C1-4 alkyl, C1-4 alkoxy or halogen; R4 is hydrogen, halogen, hydroxy, C1-4 alkyl or C1-4 alkoxy, R5 is hydrogen or fluorine, R6 is hydrogen or fluorine, R7 is halogen; and n is 1 or 2, have anti-obesity and/or anti-hyperglycaemic activity.
- -
-
-