- Asymmetric synthesis and determination of the absolute configuration of FK584, an agent for the treatment of overactive detrusor
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FK584[(-)-N-tert-butyl-4,4-diphenyl-2-cyclopentenylamine hydrochloride, (-)-4·HCl], a potential candidate for the treatment of overactive detrusor, was synthesized in a 4-step approach starting with Sharpless oxidation of cyclopentenol 6 (kinetic resoluti
- Take,Okumura,Tsubaki,Taniguchi,Shiokawa
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p. 1903 - 1907
(2007/10/03)
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- Agents for the treatment of overactive detrusor. VIII. Synthesis and pharmacological properties of 4,4-diphenyl-2-cycloalkenylamines including FK584 and 3,3- or 4,4-diphenylcycloalkylamines
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This article describes the synthesis of 4,4-diphenyl-2-cycloalkenylamines (3, 5a) including PK584 (S(-)-3a) and 3,3- or 4,4-diphenylcycloalkylamines (2, 4, 5b), and their inhibitory activities against detrusor contraction. The order of inhibitory activity
- Taniguchi,Okumura,Take,Tsubaki,Terai,Nakanishi,Shiokawa
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