The present invention provides an improved process for the preparation of Dolasetron salts, in particularly Dolasetron mesylate. % Also provided are intermediates for the process and methods of preparing the intermediates.
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Page/Page column 45; 50
(2008/06/13)
Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one and related compounds
The present invention is directed to a group of esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(3H)-ones and related compounds. The compounds are prepared from the appropriate carboxylic acids and alcohols by standard procedures or, where steric factors are significant, a new process which makes use of heavy metal salts of super acids can be used. The compounds involved are useful in the treatment of migraine and similar disorders and in cytotoxic drug-induced vomiting.
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(2008/06/13)
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