- HEXONE GLUCOKINASE INHIBITOR AND USE THEREOF
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The present invention relates to the technical field of pharmaceuticals, and in particular to a ketohexokinase inhibitor compound, a pharmaceutically acceptable salt, an ester or a stereoisomer thereof; a pharmaceutical composition and formulation containing the compound, the pharmaceutically acceptable salt, the ester or the stereoisomer thereof; a method for preparing the compound, the pharmaceutically acceptable salt, the ester or the stereoisomer thereof; and use of the compound, the pharmaceutically acceptable salt, the ester or the stereoisomer thereof in the manufacture of a medicament for treating and/or preventing KHK-mediated diseases and related conditions.
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- CUPRIC ION-CATALYZED DIOXYGENATION OF 1,2-CYCLOHEXANEDIONES. A NONENZYMATIC ANALOG FOR QUERCETINASE DIOXYGENATION
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1,2-Cyclohexanediones were found to be dioxygenated by molecular oxygen with the aid of cupric ion to afford 1,5-keto acids and carbon monoxide.The reaction proceeds possibly via an endoperoxide intermediate.Methyl α-hydroxyadipates were also formed as byproducts.The mechanism of oxygenation is discussed.
- Utaka, Masanori,Hojo, Makoto,Fujii, Yasuyuki,Takeda, Akira
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p. 635 - 638
(2007/10/02)
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