A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation
A simple and efficient approach for the synthesis of 2-aminoquinazoline derivatives in moderate to good yields. This reaction employs mild reaction conditions, is metal-free and utilizes readily available starting materials making it a more viable reaction for scale up synthesis and ligand diversity. Notably, this methodology allows for the synthesis of 2-aminoquinazolines using a free amine or cyclic amine enabling structural diversity and good atom economy.
Efficient copper-catalyzed synthesis of 2-amino-4(3h)-quinazolinone and 2-aminoquinazoline derivatives
We have developed a versatile and efficient method for copper-catalyzed synthesis of both 2-amino-4(3H)-quinazolinone and 2-aminoquinazoline derivatives. The protocol uses readily available substituted 2-halobenzoic acids, 2-bromobenzaldehyde, 2-bromophen
Synthesis of 2-Aminoquinazolines from ortho-Fluoroketones
The reactions of ten ortho-fluoroketones with guanidine carbonate in N,N-dimethylacetamide were investigated as a new synthetic approach to 2-amino-4-alkyl- and 2-amino-4-arylquinazolines.The yields obtained ranged from low to moderate and were highly dep
Hynes, John B.,Campbell, Johnny P.,Hynes, John D.
p. 1185 - 1188
(2007/10/02)
SYNTHESIS OF 5H-DIPYRIDOPYRIMIDIN-5-ONE AND 5-H-PYRIDOPYRIMIDOQUINAZOLIN-5-ONES
α-Amino-N-heteroarenes on cyclocondensation with 2-chloropyridine-3-carboxylic acid chloride afford the title compounds 4 and 7.Although compound 4 is obtained in one-pot while compound 7 is formed via its amide intermediate 6.