- METALLOENZYME INHIBITOR COMPOUNDS
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Provided are compounds having HDAC6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by HDAC6.
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- SERINE/THREONINE KINASE INHIBITORS
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Compounds having the formula I wherein R2, X and Z as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
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Paragraph 0478-0479
(2014/03/25)
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- Preparation and use of α-bromomono- and -bromobis-difluoromethoxyacetophenones in the synthesis of polymethyleneimidazoles with an angular nitrogen atom
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The synthesis of α-bromo-4-difluoromethoxy- and α-bromo-2,4-bis(difluoromethoxy)acetophenones has been earned out. Conditions have been studied for condensing the latter with cyclic tri- and tetramethylenamidinines and with pyridine-containing derivatives. A series of pyrrolo[1,2-a]imidazole and imidazo[2,1-a]pyridine derivatives containing difluoromethoxy groups has been synthesized. 1998 Plenum Publishing Corporation.
- Demchenko,Nazarenko,Fedyuk,Fialkov,Shelyazhenko,Yagupol'skii
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p. 1191 - 1195
(2007/10/03)
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- Thiadiazinones
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Compounds of formula I STR1 in which R1 and R2 are each independently of one another H or A, R3 is H, OA or O--Cm H2m+1-n Xn, R4 is --O--Cm H2m+1-n Xn, X is F or Cl, A is alkyl having 1-6 C atoms, m is 1, 2, 3, 4, 5 or 6 and n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13, and their salts have positive ionitropic activity and vasodilating action, and promote circulation. In addition, the compounds can be employed for the treatment of asthmatic disease and memory disorders, and have anti-depressive and anti-inflammatory properties.
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- N-aryl-3-aryl-4-substituted-2,3,4,5-tetrahydro-1H-pyrazole-1-carboxamides
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This invention relates to novel N-aryl-3-aryl-4-substituted-2,3,4,5-tetrahydro-1H-pyrazole-1-carboxamide compounds which are useful as pesticides, compositions containing those compounds, methods of controlling pests and processes for preparing these compounds.
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