A simple, general and improved procedure for phosphorylation of alcohols catalyzed by indium(III) chloride
A general and efficient procedure has been developed for the preparation of dialkyl phosphate esters by indium(III) chloride catalyzed phosphoryl transfer from diethyl and diphenyl chlorophosphate to a variety of alcohols and phenols in THF in presence of triethylamine.
Ranu, Brindaban C.,Das, Arijit
p. 1063 - 1064
(2007/10/03)
TRANSITION METHAL-CATALYZED SUBSTITUTION REACTION OF ALLYLIC PHOSPHATES WITH GRIGNARD REAGENTS
SN2-selective Grignard coupling with primary allylic diphenylphosphates was successfully achieved using Ni or Fe catalyst.In sharp contrast, a catalytic amount of CuCN*2LiCl promoted a SN2'-selective coupling reaction.In the presence of the copper catalyst, stereochemically homogeneous γ-disubstituted allyl Grignard reagents reacted at the less substituted allylic terminus (α-position) with an allylic diphenylphosphate selectively without losing the double bond geometry.