- Reversible Stereoselective Folding/Unfolding Fueled by the Interplay of Photoisomerism and Hydrogen Bonding
-
A linear molecular architecture equipped with complementary three-fold hydrogen-bonding units embedded with a photoswitchable trans-tetrafluoroazobenzene moiety was synthesized. The transto cis photoisomerism of the azobenzene unit induced drastic changes
- Opie, Christopher R.,Kumagai, Naoya,Shibasaki, Masakatsu
-
-
Read Online
- Active ester functionalized azobenzenes as versatile building blocks
-
Azobenzenes are important molecular switches that can still be difficult to functionalize selectively. A high yielding Pd-catalyzed cross-coupling method under mild conditions for the introduction of NHS esters to azobenzenes and diazocines has been established. Yields were consistently high with very few exceptions. The NHS functionalized azobenzenes react with primary amines quantitatively. These amines are ubiquitous in biological systems and in material science.
- Schultzke, Sven,Staubitz, Anne,Walther, Melanie
-
supporting information
(2021/07/12)
-
- COMPOSITION AND METHOD FOR MANUFACTURING RESINS
-
Certain embodiments of the invention described herein comprise a composition of matter, and method for preparing the same, which provide the benefits of pre-reaction molecular configuration favoring high liquidity properties, and post-reaction configurati
- -
-
Paragraph 0182
(2021/05/07)
-
- Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N and E138K Mutants and Pharmacokinetic Profiles
-
Molecular hybridization is a powerful strategy in drug discovery. A series of novel diarylbenzopyrimidine (DABP) analogues were developed by the hybridization of FDA-approved drugs etravirine (ETR) and efavirenz (EFV) as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs). Substituent modifications resulted in the identification of new DABPs with the combination of the strengths of the two drugs, especially compound 12d, which showed promising activity toward the EFV-resistant K103N mutant. 12d also had a favorable pharmacokinetic (PK) profile with liver microsome clearances of 14.4 μL/min/mg (human) and 33.2 μL/min/mg (rat) and an oral bioavailability of 15.5% in rat. However, its activity against the E138K mutant was still unsatisfactory; E138K is the most prevalent NNRTI resistance-associated mutant in ETR treatment. Further optimizations resulted in a highly potent compound (12z) with no substituents on the phenyl ring and a 2-methyl-6-nitro substitution pattern on the 4-cyanovinyl-2,6-disubstitued phenyl motif. The antiviral activity of this compound was much higher than those of ETR and EFV against the WT, E138K, and K103N variants (EC50 = 3.4, 4.3, and 3.6 nM, respectively), and the cytotoxicity was decreased while the selectivity index (SI) was increased. In particular, this compound exhibited acceptable intrinsic liver microsome stability (human, 34.5 μL/min/mg; rat, 33.2 μL/min/mg) and maintained the good PK profile of its parent compound EFV and showed an oral bioavailability of 16.5% in rat. Molecular docking and structure-activity relationship (SAR) analysis provided further insights into the binding of the DABPs with HIV-1 reverse transcriptase and provided a deeper understanding of the key structural features responsible for their interactions.
- Han, Sheng,Sang, Yali,Wu, Yan,Tao, Yuan,Pannecouque, Christophe,De Clercq, Erik,Zhuang, Chunlin,Chen, Fen-Er
-
-
- O -fluoroazobenzenes as readily synthesized photoswitches offering nearly quantitative two-way isomerization with visible light
-
Azobenzene functionalized with ortho-fluorine atoms has a lower energy of the n-orbital of the Z-isomer, resulting in a separation of the E and Z isomers' n→π* absorption bands. Introducing para-substituents allows for further tuning of the absorption spe
- Bleger, David,Schwarz, Jutta,Brouwer, Albert M.,Hecht, Stefan
-
supporting information
p. 20597 - 20600
(2013/02/22)
-
- Synthesis of fluorine-containing molecular rotors and their assembly on gold nanoparticles
-
A series of eight rotors containing thiol groups for attachment to gold surfaces and fluorine atoms for solid-state 19F NMR spectroscopy have been prepared through linear, multistep synthesis. The common rotating part of the rotors (rotator), c
- Thibeault, Dominic,Auger, Michele,Morin, Jean-Francois
-
experimental part
p. 3049 - 3067
(2010/08/07)
-
- Photochemistry of fluorinated 4-iodophenylnitrenes: Matrix isolation and spectroscopic characterization of phenylnitrene-4-yls
-
(Chemical Equation Presented) The photochemistry of a series of fluorinated p-iodophenyl azides 2 has been investigated using matrix isolation IR and EPR spectroscopy. In all cases, the corresponding phenylnitrenes 1 were formed as primary photoproducts. Further irradiation of the nitrenes 1 resulted in the formation of azirines 3, ketenimines 4, and nitreno radicals 5. The yield of 5 depends on the number of ortho fluorine substituents: with two ortho fluorine atoms the highest yield is observed, whereas without fluorine atoms the yield is too low for IR spectroscopic detection. The interconversion between the isomers 1, 3, and 4 proved to be rather complex. If the fluorine atoms are distributed unsymmetrically, two isomers of azirines 3 and ketenimines 4 can be formed. The yields of these isomers depend critically on the irradiation conditions. 2009 American Chemical Society.
- Grote, Dirk,Sander, Wolfram
-
supporting information; experimental part
p. 7370 - 7382
(2010/02/28)
-
- HIV INHIBITING 1,2,4-TRIAZIN-6-ONE DERIVATIVES
-
The present invention relates to HIV replication inhibitors of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein ring A and ring B represent phenyl, pyridyl, pyridaz
- -
-
Page/Page column 54
(2008/06/13)
-
- NOVEL COMPOUNDS, ISOMER THEREOF OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
-
This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1 )antagonist; and a pharmaceutical composition containing the same. The present invention
- -
-
Page/Page column 77
(2010/11/23)
-
- HIV INHIBITING 1,2,4-TRIAZINES
-
The present invention relates to HIV replication inhibitors of formula (I) as defined in the specification their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.
- -
-
-
- Tolan derivatives, liquid crystal compositions including same, liquid crystal display devices including the compositions and method of preparation
-
A tolan derivative suitable for use in a liquid crystal composition represented by the general formula: STR1 wherein R is a straight chain alkyl group having from 1 to 10 carbon atoms, A is either STR2 or a single bond, and X is hydrogen or fluorine.
- -
-
-
- Tolane derivatives, liquid crystal compositions containing the derivatives and liquid crystal display devices using the compositions
-
A tolane derivative, a liquid crystal composition containing the derivative, and a liquid crystal display device including the composition, in which the tolane derivative is represented by the following general formula: STR1 wherein R represents a straigh
- -
-
-