14189-53-8

The invention belongs to the technical field of medical and natural compound chemical intermediates and related chemistry, and provides a method for preparing alcohol compounds through a hydrogenationreduction of ketone and aldehyde. Ketone, aldehyde and derivatives thereof, which are used as raw materials, are subjected to hydrogenation reduction with nano-porous palladium as a catalyst and hydrogen as a hydrogen source, wherein the pressure of hydrogen is 0.1-0.5 MPa, the molar concentration of the ketone, aldehyde and derivatives thereof in the solvent is 0.01-2 mmol/m, the pore skeleton size of the adopted catalyst is 1-50 nm, and the molar ratio of ketone, aldehyde and derivatives thereof to the catalyst is 1:0.01 to 1:0.5. The method has the advantages of high product yield, very mild reaction conditions, simplicity in operation and post-treatment, good repeatability of the catalyst, no obvious reduction of the catalytic effect after the catalyst is used for many times, and provision of the possibility for industrialization.

An efficient and convenient one-pot synthesis of indene derivatives was achieved in moderate to high yields by the CF3SO3H promoted coupling/cyclization reaction of benzylic alcohols and 1,3-dicarbonyls for the first time. For the reactions of methoxy- or methyl-substituted diarylmethanols with 1,3-dicarbonyls, 2 equiv of CF3SO3H was needed to reach the best results; but for the reactions of methoxy-substituted arylethanols with 1,3-dicarbonyls, 0.6 equiv of CF 3SO3H at lower temperatures was capable of promoting the reaction finished.

Palladium-catalyzed dual C-H functionalization of benzophenones to form fluorenones by oxidative dehydrogenative cyclization is reported. This method provides a concise and effective route toward the synthesis of fluorenone derivatives, which shows outstanding functional group compatibility.