- Decarboxylative alkylation of β-keto Acids with isochromans under oxidative conditions
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An unprecedented decarboxylative alkylation reaction of β-keto acids with isochromans has been developed under oxidative conditions. A range of β-keto acids smoothly undergo decarboxylative alkylation with isochromans in the presence of 2,2,6,6-tetramethylpiperdine-1-oxoammonium hexafluorophosphate to give structurally diverse 1-acylmethylisochromans in moderate to excellent yields with extremely high regioselectivity. A range of β-keto acids smoothly undergo decarboxylative alkylation with isochromans in the presence of 2,2,6,6-tetramethylpiperdine-1-oxoammonium hexafluorophosphate to give structurally diverse 1-acylmethylisochromans in moderate to excellent yields. Copyright
- Chen, Yan,Tian, Shi-Kai
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supporting information
p. 37 - 39
(2013/08/24)
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