- Conjugate addition of a primary carbon radical to α,β-unsaturated carboxylic acids
-
Triethylborane in the presence of trace oxygen was employed simultaneously as a radical initiator and carboxyl protecting group to promote the conjugate radical addition of 2-phenethyl iodide to α,β- unsaturated carboxylic acids in good yields. (C) 2000 Elsevier Science Ltd.
- Wu, Baogen,Avery, Bonnie A.,Avery, Mitchell A.
-
-
Read Online
- PYRROLIDINE AMIDE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS
-
The present invention relates to compounds of formula (I) useful as inhibitors of one or more histone demethylses, such as KDM5. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and the compounds for use in methods for the treatment of various disorders. Formula (I): or a salt thereof, wherein: A is selected from the group consisting of:
- -
-
Page/Page column 88
(2016/05/02)
-
- METHODS, SYSTEMS, AND COMPOSITIONS FOR PROMOTING BONE GROWTH
-
The present invention relates to novel bone compositions for locally delivering a therapeutic agent to the site of a bone defect. Therapeutic agents may promote repair of the bone defect and/or treat conditions or disorders such as pain, inflammation, cancer, and infection. The compositions include calcium phosphate cements and a demineralized bone matrix or a collagen sponge. The compositions are useful for implantation in a patient at the site of a bone defect.
- -
-
Paragraph 0665-0666
(2015/02/02)
-
- DIFLUOROLACTAM COMPOSITIONS FOR EP4-MEDIATED OSTEO RELATED DISEASES AND CONDITIONS
-
Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.
- -
-
Paragraph 0555-0556
(2014/02/15)
-
- METHODS OF SYNTHESIZING A DIFLUOROLACTAM ANALOG
-
The present invention relates to processes and intermediates for preparing compounds of formula (IA), wherein R1, R4, R5, R6, and L1 are as defined herein. Compounds of formula (IA) have been found useful as EP4 receptor agonists useful in the treatment of glaucoma, osteoporosis, neuropathic pain, and related disorders.
- -
-
Paragraph 00437; 00438
(2014/09/29)
-
- LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS
-
Disclosed herein are compounds of formula (I) wherein L1, L2, L3, R1, R4, R5, and R6 are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.
- -
-
Paragraph 0453; 0476; 0477
(2014/09/29)
-
- Lipase-mediated preparation of optically active isomers of Rosaphen
-
The optically active isomers of Rosaphen (RS)-1 were synthesized from the chiral intermediate prepared by lipase-catalyzed desymmetrization of prochiral diol. The results of an olfactory evaluation of the prepared isomers are reported.
- Kawasaki, Masashi,Toyooka, Naoki,Saka, Tomoki,Goto, Michimasa,Matsuya, Yuji,Kometani, Tadashi
-
experimental part
p. 135 - 142
(2010/12/20)
-
- Novel pyridopyprimidinone derivatives which are HM74A agonists
-
The invention is concerned with novel pyridopyrimidinone derivatives of formula (I): wherein R1 to R8, X, Y, m and n are as defined in the description and in the claims. The compounds of the present invention are HM74A agonists with
- -
-
Page/Page column 25
(2008/06/13)
-