Isothiourea-Catalyzed Atroposelective N-Acylation of Sulfonamides
We report herein an atroposelective N-acylation of sulfonamides using a commercially available isothiourea catalyst, (S)-HBTM, with a simple procedure. The N-sulfonyl anilide products can be obtained in good to high enantiopurity, which represents a new axially chiral scaffold. The application of the product as a chiral iodine catalyst is also demonstrated for the asymmetric α-oxytosylation of propiophenone.
Ong, Jun-Yang,Ng, Xiao Qian,Lu, Shenci,Zhao, Yu
supporting information
p. 6447 - 6451
(2020/09/02)
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