- CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
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An object of the present invention is to provide a compound exerting an analgesic effect against pain, in particular, neuropathic pain and/or fibromyalgia syndrome. The present invention provides a cyclic amine derivative represented by the following general formula, or a pharmacologically acceptable salt thereof.
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Paragraph 0372; 0373
(2018/02/03)
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- CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
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A compound exerts a strong analgesic effect against pain, in particular, neuropathic pain and/or fibromyalgia syndrome. The cyclic amine derivative is represented by formula, a prodrug thereof or a pharmacologically acceptable salt thereof: wherein A represents a group represented by Formula (IIa), (IIb) or (IIc): wherein R3 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R4 represents a hydrogen atom or an alkylcarbonyl group having 2 to 6 carbon atoms or an alkyl group having 1 to 6 carbon atoms and optionally substituted with an alkylcarbonylamino group having 2 to 6 carbon atoms and n represents 1 or 2, in which when R3 and R4 each independently represent an alkyl group having 1 to 6 carbon atoms, R1 represents an alkyl group having 1 to 6 carbon atoms and substituted with a hydroxyl group, an amino group or a carboxyl group.
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- Cyclic amine derivative and pharmaceutical use thereof
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The purpose of the present invention is to provide a compound that exerts a strong analgesic action against on pain, in particular, against neuropathic pain and/or fibromyalgia syndrome. The present invention provides a cyclic amine derivative represented by chemical formula, a prodrug thereof or a pharmaceutically acceptable salt thereof.
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Paragraph 0316
(2016/10/09)
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- NOVEL FURANONE DERIVATIVE
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To provide a novel furanone derivative, and a medicine including the same. The furanone derivative is represented by the formula (I): wherein A represents —COOR1 or a hydrogen atom; R1 represents a hydrogen atom, an optionally substituted hydrocarbon grou
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Paragraph 0722; 0723
(2014/02/16)
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- Synthesis and biological studies of 1-amino β-carbolines
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A selection of amino-substituted β-carbolines have been prepared and show anticancer and antimalarial activities. A selection of 1-amino-substituted β-carbolines have been prepared by amination of 1-chloro-β-carboline as simple mimics of manzamine A and chloroquine and their intercalating ability, anticancer and antimalarial activity were studied.
- Boursereau, Yohan,Coldham, Iain
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p. 5841 - 5844
(2007/10/03)
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