Synthesis of (Z)-3-Benzylidene-3,4-dihydro-2-oxo-2H-1,4-benzoxazine-5-carboxylic Acid, a Naturally Occuring Inhibitor of Glutathione S-Transferase
Preparation of a number of 2H-1,4-benzoxazin-2-ones has been effected by reaction of substituted 2-aminophenols with methyl 3-phenylpyruvate.This methodology has been applied to afford a rapid and efficient synthesis of the naturally occuring glutathione S-transferase inhibitor (Z)-3-benzylidene-3,4-dihydro-2-oxo-2H-1,4-benzoxazine-5-carboxylic acid.
Kelly, T. Ross,Martinez, Carmen,Mears, Richard J.
p. 87 - 94
(2007/10/03)
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