Iron-catalyzed oxidative amidation of tertiary amines with aldehydes
Unconventional couple: A new oxidative coupling protocol for amide bond formation has been developed (see scheme). The method provides an efficient and practical route for the synthesis of tertiary amides from readily available tertiary amines and aldehydes in the presence of a simple FeCl2 catalyst. Mechanistic studies indicated that a peroxide and an iminium ion act as the reactive intermediates in this oxidative amidation.
Li, Yuanming,Jia, Fan,Li, Zhiping
supporting information
p. 82 - 86
(2013/03/13)
Tandem Radical Translocation and Homolytic Aromatic Substitution: a Convenient and Efficient Route to Oxindoles
Suitable o-bromo-N-methylanilides are efficiently converted into oxindoles by treatment with tributylstannane at 160 degC via tandem translocation of the initially formed aryl radical and intramolecular homolytic substitution.
Beckwith, Athelstan L. J.,Storey, John M. D.
p. 977 - 978
(2007/10/02)
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