Two convenient regioselective syntheses of 1-N-alkyl-3-aryl-4-[pyrimidin-4-yl]-pyrazoles
Two regioselective synthetic routes for 1-N-alkyl-3-aryl-4-[pyrimidin-4-yl]-pyrazoles of generic formula 1 were developed. These highly efficient and scalable routes circumvent the generally observed poor regioselectivity for the pyrazole alkylation.
Ralph, Jeffrey M.,Faitg, Thomas H.,Silva, Domingos J.,Feng, Yanhong,Blackledge, Charles W.,Adams, Jerry L.
scheme or table
p. 1377 - 1380
(2009/06/08)
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